Journal of Parkinson's Disease2026
The central cholinergic system as a therapeutic target in Parkinson's disease
Miller SJ, Yue JS, Bozal SB, Logan R, Hafler BP
Journal of Parkinson's Disease, 16(3): 391–415
NeurodegenerationParkinson's Disease
Scholarship
Publications
Peer-reviewed research from the Miller Lab. For the most current list, see Dr. Miller's Google Scholar profile.
25 papers
Journal Articles
Neuron2026
A hierarchical electrical synaptic circuit mechanism for integrative parallel visual processing in the retina
Xue Y, Fei Y, DiStasio M, Miller SJ, Hafler BP, Liang L, Lee S, Zhou ZJ
Neuron, 114(9): 1651–1665.e6
Retinal Biology
Alzheimer's & Dementia2026
Intracellular protein GBF1 displays significant associations with amyloid pathology in Alzheimer's disease
Miller SJ, Prokopenko D, Bai P, Mondal P, Scott A, Zhang W, Gomm A, Zhang S, Child DD, Shen N, Ward J, Schulte S, Lei D, Hafler BP, Wang C, Tanzi RE, Zhang C
Alzheimer's & Dementia, 22(4): e71271
Alzheimer's DiseaseNeurodegeneration
Glia2026
Astrocyte MCT1 Expression Does Not Contribute to the Axonal Degenerative Phenotype Observed With Ubiquitous MCT1 Depletion
Philips T, Thompson EG, Spead O, Vijayakumar BG, Kent ER, Miller SJ, Nwokeleme T, Vidensky S, Farah MH, Rothstein JD
Glia, 74(2): e70113
Neurodegeneration
Science Advances2025
SARS-CoV-2 induces Alzheimer's disease-related amyloid-β pathology in ex vivo human retinal explants and retinal organoids
Miller SJ, Dhodapkar RM, Sutova HE, Xue Y, Lee S, Logan R, Ran C, Bhatta S, Gomm A, Ju IG, Heyang M, Darji RY, DiStasio M, Tanzi RE, Zhang C, Zhou ZJ, Hafler BP
Science Advances, 11(27): eads5006
Alzheimer's DiseaseLong COVIDRetinal Biology
Frontiers in Cellular and Infection Microbiology2025
The amyloid-beta wave hypothesis of Alzheimer's disease
Miller SJ, Logan R, Zhang C, Hafler BP
Frontiers in Cellular and Infection Microbiology, 15: 1723095
Alzheimer's DiseaseNeurodegeneration
Neuroglia2024
R-Spondin 1 Suppresses Inflammatory Cytokine Production in Human Cortical Astrocytes
Logan R, Bhatta S, Sutova HE, Hafler BP, Miller SJ
Neuroglia, 5(4): 445–451
NeurodegenerationDOI
Frontiers in Neurology2023
Senolytic and senomorphic secondary metabolites as therapeutic agents in Drosophila melanogaster models of Parkinson's disease
Miller SJ, Darji RY, Walaieh S, Lewis JA, Logan R
Frontiers in Neurology, 14: 1271941
NeurodegenerationParkinson's Disease
Frontiers in Neuroscience2022
Neuroglial Senescence, α-Synucleinopathy, and the Therapeutic Potential of Senolytics in Parkinson's Disease
Miller SJ, Campbell CE, Jimenez-Corea HA, Wu GH, Logan R
Frontiers in Neuroscience, 16: 824191
NeurodegenerationParkinson's Disease
Frontiers in Aging Neuroscience2021
Deep Convolutional Neural Networks With Ensemble Learning and Generative Adversarial Networks for Alzheimer's Disease Image Data Classification
Logan R, Williams BG, Ferreira da Silva M, Indani A, Schcolnicov N, Ganguly A, Miller SJ
Frontiers in Aging Neuroscience, 13: 720226
Alzheimer's Disease
Journal of Alzheimer's Disease2020
Upregulation of Alzheimer's Disease Amyloid-β Protein Precursor in Astrocytes Both in vitro and in vivo
Liang Y, Raven F, Ward JF, Zhen S, Zhang S, Sun H, Miller SJ, Choi SH, Tanzi RE, Zhang C
Journal of Alzheimer's Disease, 76(3): 1071–1082
Alzheimer's DiseaseNeurodegeneration
Nature Neuroscience2019
Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin
Miller SJ, Philips T, Kim N, Dastgheyb R, Chen Z, Hsieh YC, Daigle JG, Datta M, Chew J, Vidensky S, Pham JT, Hughes EG, Robinson MB, Sattler R, Tomer R, Suk JS, Bergles DE, Haughey N, Pletnikov M, Hanes J, Rothstein JD
Nature Neuroscience, 22(5): 741–752
Neurodegeneration
Journal of Neurogenetics2018
Cortical astroglia undergo transcriptomic dysregulation in the G93A SOD1 ALS mouse model
Miller SJ, Glatzer JC, Hsieh YC, Rothstein JD
Journal of Neurogenetics, 32(4): 322–335
Neurodegeneration
Science2018
Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model
Choi SH, Bylykbashi E, Chatila ZK, Lee SW, Pulli B, Clemenson GD, Kim E, Rompala A, Oram MK, Asselin C, Aronson J, Zhang C, Miller SJ, Lesinski A, Chen JW, Kim DY, van Praag H, Spiegelman BM, Gage FH, Tanzi RE
Science, 361(6406)
Alzheimer's Disease
Neuron2018
Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease
Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, Corjuc BT, DeVos SL, Gonzalez JA, Chew J, Vidensky S, Gage FH, Mertens J, Troncoso J, Mandelkow E, Salvatella X, Lim RYH, Petrucelli L, Wegmann S, Rothstein JD, Hyman BT
Neuron, 99(5): 925–940.e7
Alzheimer's DiseaseNeurodegeneration
Frontiers in Cellular Neuroscience2018
Astrocyte Heterogeneity in the Adult Central Nervous System
Miller SJ
Frontiers in Cellular Neuroscience, 12: 401
Neurodegeneration
EBioMedicine2017
Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1
Raven F, Ward JF, Zoltowska KM, Wan Y, Bylykbashi E, Miller SJ, Shen X, Choi SH, Rynearson KD, Berezovska O, Wagner SL, Tanzi RE, Zhang C
EBioMedicine, 24: 93–101
Alzheimer's Disease
Biological Procedures Online2017
3D Printer Generated Tissue iMolds for Cleared Tissue Using Single- and Multi-Photon Microscopy for Deep Tissue Evaluation
Miller SJ, Rothstein JD
Biological Procedures Online, 19: 7
Journal of Neurogenetics2017
Astroglial transcriptome dysregulation in early disease of an ALS mutant SOD1 mouse model
Miller SJ, Zhang PW, Glatzer J, Rothstein JD
Journal of Neurogenetics, 31(1-2): 37–48
Neurodegeneration
PLoS One2016
Astroglia in Thick Tissue with Super Resolution and Cellular Reconstruction
Miller SJ, Rothstein JD
PLoS One, 11(8): e0160391
Nature2015
The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
Zhang K, Donnelly CJ, Haeusler AR, Grima JC, Machamer JB, Steinwald P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, Thomas MA, Hong I, Chiu SL, Huganir RL, Ostrow LW, Matunis MJ, Wang J, Sattler R, Lloyd TE, Rothstein JD
Nature, 525(7567): 56–61
Neurodegeneration
Journal of Biological Chemistry2014
Cyclopamine modulates γ-secretase-mediated cleavage of amyloid precursor protein by altering its subcellular trafficking and lysosomal degradation
Vorobyeva AG, Lee R, Miller S, Longen C, Sharoni M, Kandelwal PJ, Kim FJ, Marenda DR, Saunders AJ
Journal of Biological Chemistry, 289(48): 33258–33274
Alzheimer's Disease
Science2013
Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models"
Veeraraghavalu K, Zhang C, Miller S, Hefendehl JK, Rajapaksha TW, Ulrich J, Jucker M, Holtzman DM, Tanzi RE, Vassar R, Sisodia SS
Science, 340(6135): 924-f
Alzheimer's Disease
PLoS One2011
Characterization of a Drosophila Alzheimer's disease model: pharmacological rescue of cognitive defects
Chakraborty R, Vepuri V, Mhatre SD, Paddock BE, Miller S, Michelson SJ, Delvadia R, Desai A, Vinokur M, Melicharek DJ, Utreja S, Khandelwal P, Ansaloni S, Goldstein LE, Moir RD, Lee JC, Tabb LP, Saunders AJ, Marenda DR
PLoS One, 6(6): e20799
Alzheimer's Disease
Preprints
Preprint · bioRxiv2025
A painless nerve growth factor variant uncouples nociceptive and neurotrophic TrkA signaling
Kumar S, Jung HA, Walker G, Rana JK, Fu R, Höng MT, Malerba F, Kumar J, Navratna V, Jung W, Miller SJ, Kruckenhauser L, Capsoni S, Hafler BP, Cattaneo A, Krishnan Y, Mosalaganti S, Bhattacharyya M